The Science of CBD
After 35 years of research, scientists have only just begun to understand the importance of the Human Endocannabinoid System (HEcS). The discovery of the HEcS is arguably the most important discovery in human physiology in the late Twentieth Century. Research has revealed that the HEcS is responsible for maintaining and controlling the body's homeostasis, or balanced regulation of every system in the body. It does that through two known receptors called CB1 & CB2.
While the body produces its own endogenous cannabinoids, many scientists suggest that most people are now suffering from "Cannabinoid Deficiency". Without sufficient cannabinoids in our diet, the HEcS operates at less than peak efficiency, resulting in a general decline in overall health. Supplementing our diets with full-spectrum phytocannabinoids may be an essential component to achieving optimal health.
The primary cannabinoid receptors are identified as Cannabinoid Type 1 receptors (CB1-R) and Cannabinoid Type 2 receptors (CB2-R). The receptors can be "unlocked" by three kinds of cannabinoids:
- 1) Endocannabinoids
Endogenous-fatty-acid cannabinoids produced naturally in the body (e.g., anandamide and 2-AG)
- 2) Phytocannabinoids
Concentrated in the oily resin of the buds and leaves of plants such as cannabis (e.g., THC and CBD)
- 3) Synthetic Cannabinoids
Manufactured by artificial means such as in a laboratory
The Endocannabinoid System is found in every animal, except for insects, and regulates a broad range of biological functions. The ECS is a biochemical control system of neuromodulatory lipids (molecules that include fats, waxes, sterols and fat-soluble vitamins such as vitamins A, D, E, K and others) and specialized receptors configured to accept certain cannabinoids. In general, a given receptor will accept only particular classes of compounds and will be unaffected by other compounds, just as a specific key is needed to open a lock.
Specialized receptors are located throughout the human body, including but not limited to, in the hippocampus (memory, learning), the cerebral cortex (decision-making, emotional behavior), the cerebellum (motor control, coordination), putamen (movement, learning), the hypothalamus (appetite, body temperature) and the amygdala (emotions). When a specific cannabinoid or combination of cannabinoids bind to a specialized receptor, an event or a series of events is triggered in the cell, resulting in a change in the cell's activity, its gene regulation and/or the signals that it sends to neighboring cells. This process is called "signal transduction."